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Article

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma.

Frontiers in immunology - 1 Jan 2022

Li Huihuang, Zu Xiongbing, Hu Jiao, Xiao Zicheng, Cai Zhiyong, Gao Ning, Chen Jinbo

Abstract excerpt

Background: Though immune checkpoint inhibitors (ICIs) exhibit durable efficacy in bladder carcinomas (BLCAs), there are still a large portion of patients insensitive to ICIs treatment. Methods: We systematically evaluated the cuproptosis patterns in BLCA patients based on 46 cuproptosis related genes and correlated these cuproptosis patterns with tumor microenvironment (TME) phenotypes and immunotherapy...

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Identifiers

PMID: 36211344
DOI: 10.3389/fimmu.2022.964393
PMCID: PMC9540537

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