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Article

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy.

ACS chemical biology - 21 Oct 2022

Peacock D Matthew, Kelly Mark J S, Shokat Kevan M

Abstract excerpt

While there has been recent success in the development of KRasG12C inhibitors, unmet needs for selective inhibitors of KRasG12D and the remaining oncogenic KRas proteins remain. Here, we applied trifluoromethyl-containing ligands of KRas proteins as competitive probe ligands to assay the occupancy of the switch II pocket by 19F NMR spectroscopy. Structure-activity-relationship studies of probe ligands increased...

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Identifiers

PMID: 36166818
DOI: 10.1021/acschembio.2c00566
PMCID: PMC9594042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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