Article
Genetic background of anti-Xga producers in Japanese blood donors.
Vox sanguinis - 1 Oct 2022
Watanabe-Okochi Naoko, Uchikawa Makoto, Tsuneyama Hatsue, Ogasawara Kenichi, Shiraishi Risako, Masuno Atsuko, Onodera Takayuki, Tsuno Nelson-Hirokazu, Muroi Kazuo
Abstract excerpt
BACKGROUND AND OBJECTIVES: The Xg blood group is composed of two antigens, Xga (XG1) and CD99 (XG2 and MIC2). The XG and CD99 are homologous genes located on pseudoautosomal region 1 of the X and Y chromosomes. The expressions of Xga and CD99 are co-regulated by a single nucleotide polymorphism (rs311103) in the GATA-1 binding region. Another mechanism of the Xg(a-) phenotype is the genomic deletion of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.