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Article

Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy

23 Aug 2022

Abstract excerpt

Transcriptional bursting is a common expression mode for most genes where independent transcription of alleles leads to different ratios of allelic mRNA from cell to cell. Here we investigated burst-like transcription and its consequences in cardiac tissue from Hypertrophic Cardiomyopathy (HCM) patients with heterozygous mutations in the sarcomeric proteins cardiac myosin binding protein C (cMyBP-C, MYBPC3) and...

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PMID: 36082122
DOI: 10.3389/fcvm.2022.987889

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