Article
Phylogenetic analysis of the viral proteins VP4/VP7 of circulating human rotavirus strains in China from 2016 to 2019 and comparison of their antigenic epitopes with those of vaccine strains.
Frontiers in cellular and infection microbiology - 1 Jan 2022
Mao Tongyao, Wang Mengxuan, Wang Jindong, Ma Yalin, Liu Xiafei, Wang Mingwen, Sun Xiaoman, Li Lili, Li Huiying, Zhang Qing, Li Dandi, Duan Zhaojun
Abstract excerpt
Group A rotaviruses (RVAs) are the most common etiological agents of severe acute diarrhea among children under 5 years old worldwide. At present, two live-attenuated RVA vaccines, LLR (G10P[15]) and RotaTeq (G1-G4, G6 P[8], P[5]), have been introduced to mainland China. Although RVA vaccines can provide homotypic and partially heterotypic protection against several strains, it is necessary to explore the genetic...
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