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Article

Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.

Briefings in functional genomics - 13 Apr 2023

Nagar Garima, Mittal Pooja, Gupta Shradheya R R, Pahuja Monika, Sanger Manisha, Mishra Ruby, Singh Archana, Singh Indrakant Kumar

Abstract excerpt

Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Its central role in several biological processes and intracellular signaling is well known. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans...

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PMID: 36003055
DOI: 10.1093/bfgp/elac026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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