Article
Functional analysis of mutant SLCO2A1 transporters found in patients with chronic enteropathy associated with SLCO2A1.
Journal of gastroenterology and hepatology - 1 Sept 2022
Seki Satowa, Tanaka Gen, Kimura Toru, Hayashida Mari, Miyoshi Jun, Matsuura Minoru, Sakurai Hiroyuki, Hisamatsu Tadakazu
Abstract excerpt
BACKGROUND AND AIM: Chronic enteropathy associated with the solute carrier organic anion transporter family member 2A1 (SLCO2A1), or CEAS, causes anemia and hypoalbuminemia in young people. Dysfunction of the SLCO2A1 transporter protein is thought to involve genetic mutation, but mutant proteins have not been functionally characterized. We examined the prostaglandin E2 (PGE2 ) transport ability of recombinant...
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