Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huogu injection alleviates SONFH by regulating adipogenic differentiation of BMSCs via targeting the miR-34c-5p/MDM4 pathway

27 Jun 2022

Abstract excerpt

Although the precise pathogenesis of steroid-induced osteonecrosis of femoral head (SONFH) is not yet fully understood, evidence shows miRNAs-mediated posttranscription control directs the adipogenesis of bone marrow mesenchymal stem cells (BMSCs) and plays a pivotal role in the SONFH processes. Huogu injection formulated according to traditional Chinese medicine (TCM) theory has been used to treat SONFH by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Joint Diseases
Share to Mesenchymal stem cell research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35772657
DOI: 10.1016/j.gene.2022.146705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huogu injection alleviates SONFH by regulating adipogenic differentiation of BMSCs via targeting the miR-34c-5p/MDM4 pathwayPMID 35772657Read ↗

LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiationSemantic proximity Read ↗

LncRNA-H19 Promotes Adipogenic Differentiation Disorder by Regulating miR-130b-3p/PPARγ Axis in Steroid-induced Osteonecrosis of Femoral HeadSemantic proximity Read ↗

The role of lncRNA RP11‐154D6 in steroid‐induced osteonecrosis of the femoral head through BMSC regulationSemantic proximity Read ↗

MicroRNA expression in bone marrow mesenchymal stem cells from mice with steroid-induced osteonecrosis of the femoral headSemantic proximity Read ↗

MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3Semantic proximity Read ↗

The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2Semantic proximity Read ↗

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem CellsSemantic proximity Read ↗

Huc-MSC-derived exosomes alleviates alcohol-induced osteonecrosis of the femoral head through targeting the miR-25-3p/GREM1 axisSemantic proximity Read ↗

Regulatory effect of microRNA‐34a on osteogenesis and angiogenesis in glucocorticoid‐induced osteonecrosis of the femoral headSemantic proximity Read ↗

CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7Semantic proximity Read ↗

Silencing MicroRNA-137-3p, which Targets RUNX2 and CXCL12 Prevents Steroid-induced Osteonecrosis of the Femoral Head by Facilitating Osteogenesis and AngiogenesisSemantic proximity Read ↗

Up-Regulation of Urinary Exosomal Hsa-microRNA-200b-3p and Hsa-microRNA-206 in Patients of Steroid-induced Osteonecrosis of Femoral HeadSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.