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Article

Robust prognostic model based on immune infiltration-related genes and clinical information in ovarian cancer.

Journal of cellular and molecular medicine - 1 Jul 2022

Zhang Xi, Kong Weikaixin, Gao Miaomiao, Huang Weiran, Peng Chao, Huang Zhuo, Xie Zhengwei, Guo Hongyan

Abstract excerpt

Immune infiltration of ovarian cancer (OV) is a critical factor in determining patient's prognosis. Using data from TCGA and GTEx database combined with WGCNA and ESTIMATE methods, 46 genes related to OV occurrence and immune infiltration were identified. Lasso and multivariate Cox regression were applied to define a prognostic score (IGCI score) based on 3 immune genes and 3 types of clinical information. The...

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Identifiers

PMID: 35735060
DOI: 10.1111/jcmm.17360
PMCID: PMC9258710

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