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Article

Relationship of Pathogenic Mutations and Responses to Zoledronic Acid in a Cohort of Osteogenesis Imperfecta Children.

The Journal of clinical endocrinology and metabolism - 18 Aug 2022

Sun Lei, Hu Jing, Liu Jiayi, Zhang Qian, Wang Ou, Jiang Yan, Xia Weibo, Xing Xiaoping, Li Mei

Abstract excerpt

CONTEXT: Osteogenesis imperfecta (OI) is a rare, heterogeneous, genetic disorder characterized by bone fragility and recurrent fractures. Bisphosphonates (BPs) are the most commonly used medications for OI, but their efficacy has great variability. OBJECTIVE: We investigated the relationship of pathogenic gene mutations and responses to zoledronic acid (ZOL) in a large cohort of children with OI. METHODS:...

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Identifiers

PMID: 35727737
DOI: 10.1210/clinem/dgac366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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