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Article

Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 1 Aug 2022

Berdan Emma L, Blanckaert Alexandre, Butlin Roger K, Flatt Thomas, Slotte Tanja, Wielstra Ben

Abstract excerpt

Supergenes offer spectacular examples of long-term balancing selection in nature, but their origin and maintenance remain a mystery. Reduced recombination between arrangements, a critical aspect of many supergenes, protects adaptive multi-trait phenotypes but can lead to mutation accumulation. Mutation accumulation can stabilize the system through the emergence of associative overdominance (AOD), destabilize the...

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PMID: 35694750
DOI: 10.1098/rstb.2021.0199
PMCID: PMC9189497

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