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Article

Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies.

Scientific data - 9 Jun 2022

Gong Binsheng, Kusko Rebecca, Jones Wendell, Tong Weida, Xu Joshua

Abstract excerpt

The lack of suitable reference genomic material to enable a transparent cross-lab study of oncopanels inspired the SEQC2 Oncopanel Sequencing Working Group to develop four reference samples, sequenced with eight oncopanels at independent test laboratories with ultra-deep sequencing depth. This rich, publicly available dataset enabled performance assessment of the clinical applicability of oncopanels. In addition,...

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PMID: 35680918
DOI: 10.1038/s41597-022-01359-6
PMCID: PMC9184574

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