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Rifampicin Resistance Associated with rpoB Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020.

Microbiology spectrum - 29 Jun 2022

Schaeffer Justine, Lippert Kathrin, Pleininger Sonja, Stöger Anna, Hasenberger Petra, Stadlbauer Silke, Heger Florian, Eigentler Angelika, Geusau Alexandra, Indra Alexander, Allerberger Franz, Ruppitsch Werner

Abstract excerpt

Due to increasing rates of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, alternative treatments should be considered. To assess rifampicin's potential as a gonorrhea treatment, we used rpoB mutations to estimate rifampicin resistance in Austrian N. gonorrhoeae isolates. We found 30% of resistant isolates clustering in three main phylogenomic branches. Rifampicin resistance was associated with...

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Identifiers

PMID: 35678576
DOI: 10.1128/spectrum.02757-21
PMCID: PMC9241671

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