Article
Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield.
Molecular plant - 1 Aug 2022
Liao Baosheng, Shen Xiaofeng, Xiang Li, Guo Shuai, Chen Shiyu, Meng Ying, Liang Yu, Ding Dandan, Bai Junqi, Zhang Dong, Czechowski Tomasz, Li Yi, Yao Hui, Ma Tingyu, Howard Caroline, Sun Chao, Liu Haitao, Liu Jiushi, Pei Jin, Gao Jihai, Wang Jigang, Qiu Xiaohui, Huang Zhihai, Li Hongyi, Yuan Ling, Wei Jianhe, Graham Ian, Xu Jiang, Zhang Boli, Chen Shilin
Abstract excerpt
Artemisia annua is the major natural source of artemisinin, an anti-malarial medicine commonly used worldwide. Here, we present chromosome-level haploid maps for two A. annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production. High-fidelity sequencing, optical mapping, and chromatin conformation capture sequencing were used to assemble...
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