Article
In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosomal Dominant Severe Congenital Neutropenia 1 and Cyclic Hematopoiesis.
TheScientificWorldJournal - 1 Jan 2022
Shinwari Khyber, Bolkov Mikhail A, Yasir Akbar Muhammad, Guojun Liu, Deryabina Svetlana S, Tuzankina Irina A, Chereshnev Valery A
Abstract excerpt
Single-nucleotide polymorphisms in the ELANE (Elastase, Neutrophil Expressed) gene are associated with severe congenital neutropenia, while the ELANE gene provides instructions for making a protein called neutrophil elastase. We identified disease susceptibility single-nucleotide polymorphisms (SNPs) in the ELANE gene using several computational tools. We used cutting-edge computational techniques to investigate...
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