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Article

Impaired ventilation during 6-min walk test in congenital central hypoventilation syndrome.

Pediatric pulmonology - 1 Jul 2022

Ghosh Radhika N, Guglani Lokesh, Westbrook Adrianna L, Mao Chad Y, Bai Shasha, Keens Thomas G, Kasi Ajay S

Abstract excerpt

BACKGROUND: Patients with congenital central hypoventilation syndrome (CCHS) can develop hypoxemia and hypercapnia during exercise. However, there is limited literature on cardiorespiratory responses during submaximal exercise and their correlation with paired-like homeobox 2B (PHOX2B) genotype. OBJECTIVES: To assess oxygen saturation (SpO2 ), end-tidal carbon dioxide (ETCO2 ), heart rate (HR), and 6-min walk...

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PMID: 35460211
DOI: 10.1002/ppul.25940

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