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A locus conferring tolerance to Theileria infection in African cattle.

PLoS genetics - 1 Apr 2022

Wragg David, Cook Elizabeth A J, Latré de Laté Perle, Sitt Tatjana, Hemmink Johanneke D, Chepkwony Maurine C, Njeru Regina, Poole E Jane, Powell Jessica, Paxton Edith A, Callaby Rebecca, Talenti Andrea, Miyunga Antoinette A, Ndambuki Gideon, Mwaura Stephen, Auty Harriet, Matika Oswald, Hassan Musa, Marshall Karen, Connelley Timothy, Morrison Liam J, Bronsvoort B Mark deC, Morrison W Ivan, Toye Philip G, Prendergast James G D

Abstract excerpt

East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic...

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Adaptor Proteins, Signal Transducing
Alleles
Apoptosis Regulatory Proteins
Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cattle Diseases

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PMID: 35446841
DOI: 10.1371/journal.pgen.1010099
PMCID: PMC9022807

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