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Article

Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2022

Vokes Natalie I, Chambers Emily, Nguyen Tom, Coolidge Alexis, Lydon Christine A, Le Xiuning, Sholl Lynette, Heymach John V, Nishino Mizuki, Van Allen Eliezer M, Jänne Pasi A

Abstract excerpt

INTRODUCTION: Patients with EGFR-mutant NSCLC experience variable duration of benefit on EGFR tyrosine kinase inhibitors. The effect of concurrent genomic alterations on outcome has been incompletely described. METHODS: In this retrospective study, targeted next-generation sequencing data were collected from patients with EGFR-mutant lung cancer treated at the Dana-Farber Cancer Institute. Clinical data were...

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Adenocarcinoma of Lung
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Kelch-Like ECH-Associated Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-E2-Related Factor 2

Protein Kinase Inhibitors

Tumor Suppressor Protein p53

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Open in PubMed Open full text

Identifiers

PMID: 35331964
DOI: 10.1016/j.jtho.2022.02.011
PMCID: PMC10478031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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