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A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease.

International journal of molecular sciences - 9 Mar 2022

Shim Kyu-Hwan, Kang Min-Ju, Bae Heewon, Kim Danyeong, Park Jiwon, An Seong-Soo A, Jeong Da-Eun

Abstract excerpt

Early-onset Alzheimer’s disease (EOAD) is characterized by the presence of neurological symptoms in patients with Alzheimer’s disease (AD) before 65 years of age. Mutations in pathological genes, including amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2), were associated with EOAD. Seventy-six mutations in PSEN2 have been found around the world, which could affect the activity of...

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Identifiers

PMID: 35328387
DOI: 10.3390/ijms23062967
PMCID: PMC8953053

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A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease.PMID 35328387Read ↗

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