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Article

Mutational Landscape of Autism Spectrum Disorder Brain Tissue.

Genes - 24 Jan 2022

Woodbury-Smith Marc, Lamoureux Sylvia, Begum Ghausia, Nassir Nasna, Akter Hosneara, O'Rielly Darren D, Rahman Proton, Wintle Richard F, Scherer Stephen W, Uddin Mohammed

Abstract excerpt

Rare post-zygotic mutations in the brain are now known to contribute to several neurodevelopmental disorders, including autism spectrum disorder (ASD). However, due to the limited availability of brain tissue, most studies rely on estimates of mosaicism from peripheral samples. In this study, we undertook whole exome sequencing on brain tissue from 26 ASD brain donors from the Harvard Brain Tissue Resource Center...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35205252
DOI: 10.3390/genes13020207
PMCID: PMC8871846

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