Article
Limitations of Nasal Nitric Oxide Measurement for Diagnosis of Primary Ciliary Dyskinesia with Normal Ultrastructure.
Annals of the American Thoracic Society - 1 Aug 2022
Raidt Johanna, Krenz Henrike, Tebbe Johannes, Große-Onnebrink Jörg, Olbrich Heike, Loges Niki Tomas, Biebach Luisa, Schmalstieg Christian, Keßler Christina, Wallmeier Julia, Dworniczak Bernd, Pennekamp Petra, Dugas Martin, Werner Claudius, Omran Heymut
Abstract excerpt
Rationale: Primary ciliary dyskinesia (PCD) is a heterogeneous, multisystem disorder characterized by defective ciliary beating. Diagnostic guidelines of the American Thoracic Society and European Respiratory Society recommend measurement of nasal nitric oxide (nNO) for PCD diagnosis. Several studies demonstrated low nNO production rates in PCD individuals, but underlying causes remain elusive. Objectives: To...
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