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Article

Modelling spatiotemporal trends in the frequency of genetic mutations conferring insecticide target-site resistance in African mosquito malaria vector species.

BMC biology - 15 Feb 2022

Hancock Penelope A, Lynd Amy, Wiebe Antoinette, Devine Maria, Essandoh John, Wat'senga Francis, Manzambi Emile Z, Agossa Fiacre, Donnelly Martin J, Weetman David, Moyes Catherine L

Abstract excerpt

BACKGROUND: Resistance in malaria vectors to pyrethroids, the most widely used class of insecticides for malaria vector control, threatens the continued efficacy of vector control tools. Target-site resistance is an important genetic resistance mechanism caused by mutations in the voltage-gated sodium channel (Vgsc) gene that encodes the pyrethroid target-site. Understanding the geographic distribution of...

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PMID: 35164747
DOI: 10.1186/s12915-022-01242-1
PMCID: PMC8845222

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