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Article

Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown.

Scientific reports - 3 Feb 2022

Desquilles Lise, Cano Luis, Ghukasyan Gevorg, Mouchet Nicolas, Landreau Clémence, Corlu Anne, Clément Bruno, Turlin Bruno, Désert Romain, Musso Orlando

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) is the receptor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing Coronavirus disease 2019 (COVID-19). Transmembrane serine protease 2 (TMPRSS2) is a coreceptor. Abnormal hepatic function in COVID-19 suggests specific or bystander liver disease. Because liver cancer cells express the ACE2 viral receptor, they are widely used as models of SARS-CoV-2...

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Source

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Identifiers

PMID: 35115564
DOI: 10.1038/s41598-021-03710-0
PMCID: PMC8814043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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