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Profiling of the full-length transcriptome in abdominal aortic aneurysm using nanopore-based direct RNA sequencing

1 Feb 2022

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a common and serious disease with a high mortality rate, but its genetic determinants have not been fully identified. In this feasibility study, we aimed to elucidate the transcriptome profile of AAA and further reveal its molecular mechanisms through the Oxford Nanopore Technologies (ONT) MinION platform. Overall, 9574 novel transcripts and 781 genes were identified by...

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PMID: 35104432
DOI: 10.1098/rsob.210172

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