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Article

UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2022

Hulshof Emma C, de With Mirjam, de Man Femke M, Creemers Geert-Jan, Deiman Birgit A L M, Swen Jesse J, Houterman Saskia, Koolen Stijn L W, Bins Sander, Thijs Anna M J, Laven Marjan M J, Hövels Anke M, Luelmo Saskia A C, Houtsma Danny, Shulman Katerina, McLeod Howard L, van Schaik Ron H N, Guchelaar Henk-Jan, Mathijssen Ron H J, Gelderblom Hans, Deenen Maarten J

Abstract excerpt

AIM: To determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. PATIENTS AND METHODS: In this prospective, multicentre, non-randomised study, patients intended for treatment with irinotecan were pre-therapeutically genotyped for UGT1A1∗28 and UGT1A1∗93. Homozygous variant carriers (UGT1A1 poor metabolisers; PMs) received an initial 30% dose reduction. The...

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PMID: 34998046
DOI: 10.1016/j.ejca.2021.12.009

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