Article
ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2022
Dessources Kimberly, Miller Kathryn M, Kertowidjojo Elizabeth, Da Cruz Paula Arnaud, Zou Youran, Selenica Pier, da Silva Edaise M, Benayed Ryma, Ashley Charles W, Abu-Rustum Nadeem R, Dogan Snjezana, Soslow Robert A, Hensley Martee L, Weigelt Britta, Chiang Sarah
Abstract excerpt
High-grade endometrial stromal sarcomas (HGESSs) are more aggressive and have higher rates of resistance to endocrine therapy than low-grade endometrial stromal sarcomas (LGESSs). The pathogenesis of hormonal resistance in these lesions has yet to be defined. Here we sought to histologically and genetically characterize 3 LGESSs and their recurrences that underwent histologic high-grade transformation following...
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