Article
A Cluster-based Method to Quantify Individual Heterogeneity in Tuberculosis Transmission.
Epidemiology (Cambridge, Mass.) - 1 Mar 2022
Smith Jonathan P, Gandhi Neel R, Silk Benjamin J, Cohen Ted, Lopman Benjamin, Raz Kala, Winglee Kathryn, Kammerer Steve, Benkeser David, Kramer Michael R, Hill Andrew N
Abstract excerpt
BACKGROUND: Recent evidence suggests transmission of Mycobacterium tuberculosis (Mtb) may be characterized by extreme individual heterogeneity in secondary cases (i.e., few cases account for the majority of transmission). Such heterogeneity implies outbreaks are rarer but more extensive and has profound implications in infectious disease control. However, discrete person-to-person transmission events in...
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