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Article

Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego.

Scientific reports - 2 Dec 2021

Watanabe Mikiko, Risi Renata, Tafuri Mary Anne, Silvestri Valentina, D'Andrea Daniel, Raimondo Domenico, Rea Sandra, Di Vincenzo Fabio, Profico Antonio, Tuccinardi Dario, Sciuto Rosa, Basciani Sabrina, Mariani Stefania, Lubrano Carla, Cinti Saverio, Ottini Laura, Manzi Giorgio, Gnessi Lucio

Abstract excerpt

The Fuegians, ancient inhabitants of Tierra del Fuego, are an exemplary case of a cold-adapted population, since they were capable of living in extreme climatic conditions without any adequate clothing. However, the mechanisms of their extraordinary resistance to cold remain enigmatic. Brown adipose tissue (BAT) plays a crucial role in this kind of adaptation, besides having a protective role on the detrimental...

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Identifiers

PMID: 34857816
DOI: 10.1038/s41598-021-02783-1
PMCID: PMC8639971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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