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Article

Favorable Response to "Memantine" in a Child with GRIN2B Epileptic Encephalopathy.

Neuropediatrics - 1 Aug 2022

Chidambaram Sathya, Manokaran Ranjith Kumar

Abstract excerpt

GRIN2B is a gene encoding GluN2B subunit under the family of N-methyl D-aspartate (NMDA) receptors, which is responsible for neurogenesis and cognitive processes. The role of NMDA receptor antagonists like memantine is being explored for therapies in drug-resistant epilepsies. Here, we present a case of a 20-month-old boy who presented with refractory epileptic spasms. Upon failure of multiple antiepileptic...

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PMID: 34844267
DOI: 10.1055/s-0041-1739130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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