Article
C-MORE: A high-content single-cell morphology recognition methodology for liquid biopsies toward personalized cardiovascular medicine.
Cell reports. Medicine - 16 Nov 2021
Furkel Jennifer, Knoll Maximilian, Din Shabana, Bogert Nicolai V, Seeger Timon, Frey Norbert, Abdollahi Amir, Katus Hugo A, Konstandin Mathias H
Abstract excerpt
Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise a robust methodology to deconvolute cardiomyocyte morphology on a single-cell level: C-MORE (cellular morphology...
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