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Article

Thrombotic manifestations of VEXAS syndrome.

Seminars in hematology - 1 Oct 2021

Groarke Emma M, Dulau-Florea Alina E, Kanthi Yogendra

Abstract excerpt

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently described autoinflammatory syndrome characterized by diffuse inflammatory manifestations, predisposition to hematological malignancy, and an association with a high rate of thrombosis. VEXAS is attributed to somatic mutations in the UBA1 gene in hematopoietic stem and progenitor cells with myeloid restriction in mature forms....

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Identifiers

PMID: 34802545
DOI: 10.1053/j.seminhematol.2021.10.006

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