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Article

ACTH for epileptic spasms in Leigh syndrome with SLC19A3 mutation can induce status dystonicus.

Epileptic disorders : international epilepsy journal with videotape - 1 Feb 2022

Hoshino Hiroki, Kanemura Hideaki

Abstract excerpt

Patients with Leigh syndrome (LS) sometimes develop epileptic spasms (ES). ACTH treatment for ES may be effective without serious adverse events in some patients with LS. Status dystonicus is a life-threatening disorder characterized by an acute exacerbation of generalized dystonia and often develops as a triggered event. The underlying pathophysiology of status dystonicus remains unclear. To our knowledge, there...

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Identifiers

PMID: 34789446
DOI: 10.1684/epd.2021.1374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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