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The Role of CD4+ T Cells and Microbiota in the Pathogenesis of Asthma

31 Oct 2021

Abstract excerpt

Asthma, a chronic respiratory disease involving variable airflow limitations, exhibits two phenotypes: eosinophilic and neutrophilic. The asthma phenotype must be considered because the prognosis and drug responsiveness of eosinophilic and neutrophilic asthma differ. CD4+ T cells are the main determinant of asthma phenotype. Th2, Th9 and Tfh cells mediate the development of eosinophilic asthma, whereas Th1 and...

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PMID: 34769255
DOI: 10.3390/ijms222111822

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