Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology.

doi:10.1016/j.biopha.2021.112181

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Article

Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2021

Zhou Wenjun, Zhu Ziye, Xiao Xiaoli, Li Chunlin, Zhang Li, Dang Yanqi, Ge Guangbo, Ji Guang, Zhu Mingzhe, Xu Hongxi

Abstract excerpt

Jiangzhi Granule is a commonly used traditional Chinese medicine for treating non-alcoholic fatty liver disease. However, its key ingredients and underlying mechanisms for attenuating nonalcoholic steatohepatitis (NASH) remain unclear. To address this issue, UPLC-TOF-MS based chemical profiling, network pharmacology and animal experimental validation were employed. First, a total of 56 main ingredients of...

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PMID: 34649337
DOI: 10.1016/j.biopha.2021.112181

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