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Article

Efficacy of a Cell-Culture–Derived Quadrivalent Influenza Vaccine in Children

13 Oct 2021

Abstract excerpt

BACKGROUND: Cell-culture-derived influenza vaccines may enable a closer antigenic match to circulating strains of influenza virus by avoiding egg-adapted mutations. METHODS: We evaluated the efficacy of a cell-culture-derived quadrivalent inactivated influenza vaccine (IIV4c) using a Madin-Darby canine kidney cell line in children and adolescents 2 to less than 18 years of age. During three influenza seasons,...

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PMID: 34644472
DOI: 10.1056/nejmoa2024848

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