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A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development

2 Oct 2021

Abstract excerpt

BACKGROUND: Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways. However, an intact network of the intercellular regulation is still lacking. RESULT: To gain an unbiased and comprehensive view of this dental cell interactome, we applied single-cell RNA-seq on immature human...

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PMID: 34600587
DOI: 10.1186/s13578-021-00691-5

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