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Metronidazole-Induced Hepatitis in a Teenager With Xeroderma Pigmentosum and Trichothiodystrophy Overlap.

Pediatrics - 1 Oct 2021

Abiona Adesoji, Cordeiro Nuno, Fawcett Heather, Tamura Deborah, Khan Sikandar G, DiGiovanna John J, Lehmann Alan R, Fassihi Hiva

Abstract excerpt

A teenage girl had the rare combined phenotype of xeroderma pigmentosum and trichothiodystrophy, resulting from mutations in the XPD (ERCC2) gene involved in nucleotide excision repair (NER). After treatment with antibiotics, including metronidazole for recurrent infections, she showed signs of acute and severe hepatotoxicity, which gradually resolved after withdrawal of the treatment. Cultured skin fibroblasts...

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Identifiers

PMID: 34593652
DOI: 10.1542/peds.2021-050360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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