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A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review

21 Nov 2020

Abstract excerpt

Lorlatinib is a third-generation ALK inhibitor that can overcome the largest number of acquired ALK resistance mutations, including the solvent-front mutation G1202R. Here, we report, for the first time, a novel, sequentially-evolved EML4-ALK variant 3 G1202R/S1206Y double mutation in cis detected in a patient with ALK -positive NSCLC after disease progression on sequential crizotinib, alectinib, and then...

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Identifiers

PMID: 34589977
DOI: 10.1016/j.jtocrr.2020.100116

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