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Evolutionary Signatures Governing the Codon Usage Bias in Coronaviruses and Their Implications for Viruses Infecting Various Bat Species.

Viruses - 16 Sept 2021

Kumar Naveen, Kaushik Rahul, Tennakoon Chandana, Uversky Vladimir N, Mishra Anamika, Sood Richa, Srivastava Pratiksha, Tripathi Meghna, Zhang Kam Y J, Bhatia Sandeep

Abstract excerpt

Many viruses that cause serious diseases in humans and animals, including the betacoronaviruses (beta-CoVs), such as SARS-CoV, MERS-CoV, and the recently identified SARS-CoV-2, have natural reservoirs in bats. Because these viruses rely entirely on the host cellular machinery for survival, their evolution is likely to be guided by the link between the codon usage of the virus and that of its host. As a result,...

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PMID: 34578428
DOI: 10.3390/v13091847
PMCID: PMC8473330

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