Article
Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology.
The Journal of pathology - 1 Jan 2022
Schrammen Peter Leonard, Ghaffari Laleh Narmin, Echle Amelie, Truhn Daniel, Schulz Volkmar, Brinker Titus J, Brenner Hermann, Chang-Claude Jenny, Alwers Elizabeth, Brobeil Alexander, Kloor Matthias, Heij Lara R, Jäger Dirk, Trautwein Christian, Grabsch Heike I, Quirke Philip, West Nicholas P, Hoffmeister Michael, Kather Jakob Nikolas
Abstract excerpt
Deep learning is a powerful tool in computational pathology: it can be used for tumor detection and for predicting genetic alterations based on histopathology images alone. Conventionally, tumor detection and prediction of genetic alterations are two separate workflows. Newer methods have combined them, but require complex, manually engineered computational pipelines, restricting reproducibility and robustness....
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