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Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis

23 Sept 2021

Abstract excerpt

Chronic Helicobacter pylori infection is a critical risk factor for gastric cancer (GC). However, only 1-3 % of people with H. pylori develop GC. In gastric carcinogenesis, non-H. pylori bacteria in the stomach might interact with H. pylori. Bacterial dysbiosis in the stomach can strengthen gastric neoplasia development via generating tumor-promoting metabolites, DNA damaging, suppressing antitumor immunity, and...

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PMID: 34556055
DOI: 10.1186/s12866-021-02315-x

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