Article
Discovery of a Novel Fusarium Graminearum Mitogen-Activated Protein Kinase (FgGpmk1) Inhibitor for the Treatment of Fusarium Head Blight.
Journal of medicinal chemistry - 23 Sept 2021
Fu Weitao, Wang Ercheng, Ke Di, Yang Hao, Chen Lingfeng, Shao Jingjing, Hu Xueping, Xu Lei, Liu Na, Hou Tingjun
Abstract excerpt
Mitogen-activated protein kinase FgGpmk1 plays vital roles in the development and virulence of Fusarium graminearum (F. graminearum), the causative agent of Fusarium head blight (FHB). However, to date, the druggability of FgGpmk1 still needs verification, and small molecules targeting FgGpmk1 have never been reported. Here, we reported the discovery of a novel inhibitor 94 targeting FgGpmk1. First, a novel hit...
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