The Predictive Values of Advanced Non-Small Cell Lung Cancer Patients Harboring Uncommon EGFR Mutations—The Mutation Patterns, Use of Different Generations of EGFR-TKIs, and Concurrent Genetic Alterations

Abstract excerpt

Introduction Epidermal growth factor receptor ( EGFR ) 19del and L858R mutation are known as “common mutations” in non-small cell lung cancer (NSCLC) and predict sensitivities to EGFR tyrosine kinase inhibitors (TKIs), whereas 20ins and T790M mutations confer drug-resistance to EGFR -TKIs. The role of the remaining uncommon EGFR mutations remains elusive. Methods We retrospectively screened a group of NSCLC...

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