Article
Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears.
Leukemia - 1 Jan 2022
Eckardt Jan-Niklas, Middeke Jan Moritz, Riechert Sebastian, Schmittmann Tim, Sulaiman Anas Shekh, Kramer Michael, Sockel Katja, Kroschinsky Frank, Schuler Ulrich, Schetelig Johannes, Röllig Christoph, Thiede Christian, Wendt Karsten, Bornhäuser Martin
Abstract excerpt
The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of standardization and inter-observer variability. Deep learning (DL) can process medical image data and provides data-driven class predictions. Here, we apply a multi-step DL approach to automatically segment cells from bone marrow images,...
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