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Article

C9orf72-G4C2 Intermediate Repeats and Parkinson's Disease; A Data-Driven Hypothesis.

Genes - 5 Aug 2021

Kobo Hila, Goldstein Orly, Gana-Weisz Mali, Bar-Shira Anat, Gurevich Tanya, Thaler Avner, Mirelman Anat, Giladi Nir, Orr-Urtreger Avi

Abstract excerpt

Pathogenic C9orf72-G4C2 repeat expansions are associated with ALS/FTD, but not with Parkinson's disease (PD); yet the possible link between intermediate repeat lengths and PD remains inconclusive. We aim to study the potential involvement of these repeats in PD. The number of C9orf72-repeats were determined by flanking and repeat-primed PCR assays, and the risk-haplotype was determined by SNP-array. Their...

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Identifiers

PMID: 34440384
DOI: 10.3390/genes12081210
PMCID: PMC8391122

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