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Article

miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway

30 Jul 2021

Abstract excerpt

The quantity of Sertoli cells in the adult testis decides the daily gamete formation, and accumulating evidence indicates that epigenetic factors regulate the proliferation of Sertoli cells. Research on the function and regulatory mechanism of microRNAs (miRNAs) in Sertoli cells has not been comprehensive yet, especially on domestic animals. In this article, we report that miR-126 controls the proliferation and...

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PMID: 34438716
DOI: 10.3390/ani11082260

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miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling PathwayPMID 34438716Read ↗

miR‐130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF‐β‐PI3K/AKT signaling pathwaySemantic proximity Read ↗

miR-638 Inhibits immature Sertoli cell growth by indirectly inactivating PI3K/AKT pathway via SPAG1 geneSemantic proximity Read ↗

MiR-126-3p promotes the cell proliferation and inhibits the cell apoptosis by targeting TSC1 in the porcine granulosa cellsSemantic proximity Read ↗

miR‐26a inhibits proliferation and promotes apoptosis in porcine immature Sertoli cells by targeting thePAK2geneSemantic proximity Read ↗

Testosterone-Dependent miR-26a-5p and let-7g-5p Act as Signaling Mediators to Regulate Sperm Apoptosis via Targeting PTEN and PMAIP1Semantic proximity Read ↗

miR‐362 knock‐down promotes proliferation and inhibits apoptosis in porcine immature Sertoli cells by targeting the RMI1 geneSemantic proximity Read ↗

Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cellsSemantic proximity Read ↗

Sertoli cell survival and barrier function are regulated by miR-181c/d-Pafah1b1 axis during mammalian spermatogenesisSemantic proximity Read ↗

Discovery of microRNAs during early spermatogenesis in chickenSemantic proximity Read ↗

Microarray-Based Approach Identifies Differentially Expressed MicroRNAs in Porcine Sexually Immature and Mature TestesSemantic proximity Read ↗

Role and action mechanisms of miR-149 and miR-31 in regulating function of pig cumulus cells and oocytesSemantic proximity Read ↗

miR-204 Regulates the Proliferation of Dairy Goat Spermatogonial Stem Cells via Targeting to Sirt1Semantic proximity Read ↗

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