Article
Radiographical Survey of Osteochondrodysplasia in Scottish Fold Cats caused by the TRPV4 gene variant.
Human genetics - 1 Nov 2021
Rorden Chris, Griswold Marilee C, Moses Nan, Berry Clifford R, Keller G Gregory, Rivas Rudy, Flores-Smith Helen, Shaffer Lisa G, Malik Richard
Abstract excerpt
The unique appearance of Scottish Fold cats is caused by a single gene variant in TRPV4, which impacts the development of cartilage. This results in the ears folding forward and variable effects on articular cartilage and bone. While some find this appearance desirable, early work demonstrated that homozygous cats with two copies of this variant develop severe radiographic consequences. Subsequent breeding...
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