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Article

The VDR FokI (rs2228570) polymorphism is involved in Parkinson's disease.

Journal of the neurological sciences - 15 Sept 2021

Agliardi Cristina, Guerini Franca Rosa, Zanzottera Milena, Bolognesi Elisabetta, Meloni Mario, Riboldazzi Giulio, Zangaglia Roberta, Sturchio Andrea, Casali Carlo, Di Lorenzo Cherubino, Minafra Brigida, Clerici Mario

Abstract excerpt

The etiology of Parkinson's disease (PD) is presumably multifactorial and likely involves interactions between genetic and environmental factors, as well as mitochondrial dysfunction, oxidative stress and inflammation. Among environmental factors, Vitamin D was reported to associate with the risk of PD. Vitamin D activity is mediated by its binding to the vitamin D Receptor (VDR), a transcriptional factor for...

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PMID: 34365149
DOI: 10.1016/j.jns.2021.117606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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