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Article

CHD4 variants are associated with childhood idiopathic epilepsy with sinus arrhythmia.

CNS neuroscience & therapeutics - 1 Oct 2021

Liu Xiao-Rong, Ye Ting-Ting, Zhang Wen-Jun, Guo Xuan, Wang Jie, Huang Shao-Ping, Xie Long-Shan, Song Xing-Wang, Deng Wei-Wen, Li Bing-Mei, He Na, Wu Qian-Yi, Zhuang Min-Zhi, Xu Meng, Shi Yi-Wu, Su Tao, Yi Yong-Hong, Liao Wei-Ping

Abstract excerpt

AIMS: CHD4 gene, encoding chromodomain helicase DNA-binding protein 4, is a vital gene for fetal development. In this study, we aimed to explore the association between CHD4 variants and idiopathic epilepsy. METHODS: Trios-based whole-exome sequencing was performed in a cohort of 482 patients with childhood idiopathic epilepsy. The Clinical Validity Framework of ClinGen and an evaluating method from five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34109749
DOI: 10.1111/cns.13692
PMCID: PMC8446219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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