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Hippocampal Subregion and Gene Detection in Alzheimer's Disease Based on Genetic Clustering Random Forest.

Genes - 1 May 2021

Li Jin, Liu Wenjie, Cao Luolong, Luo Haoran, Xu Siwen, Bao Peihua, Meng Xianglian, Liang Hong, Fang Shiaofen

Abstract excerpt

The distinguishable subregions that compose the hippocampus are differently involved in functions associated with Alzheimer's disease (AD). Thus, the identification of hippocampal subregions and genes that classify AD and healthy control (HC) groups with high accuracy is meaningful. In this study, by jointly analyzing the multimodal data, we propose a novel method to construct fusion features and a classification...

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PMID: 34062866
DOI: 10.3390/genes12050683
PMCID: PMC8147351

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